InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GPSM1

Summary

InnateDB Gene

IDBG-92256.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPSM1

Gene Name

G-protein signaling modulator 1

Synonyms

AGS3

Species

Homo sapiens

Ensembl Gene

ENSG00000160360

Encoded Proteins

IDBP-92258

G-protein signaling modulator 1

IDBP-92260

G-protein signaling modulator 1

IDBP-244622

G-protein signaling modulator 1

IDBP-383840

G-protein signaling modulator 1

IDBP-383849

G-protein signaling modulator 1

IDBP-812892

G-protein signaling modulator 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21209316

GPSM1, an inhibitor of GNAI3, plays a key role in regulating autophagy; the dynamic interplay between GNAI3, GPSM1, and CCDC88A determines whether autophagy is promoted or inhibited. During starving conditions, GPSM1 binds to GNAI3 in MAP1LC3A-positive membranes to promote autophagy. When stimulated by growth factors, CCDC88A promotes the dissociation of GPSM1::GNAI3 complex to initiate anti-autophagy signalling pathways.

InnateDB Annotation from Orthologs

Summary

PMID 21209316

[Mus musculus] Gpsm1, an inhibitor of Gnai3, plays a key role in regulating autophagy; the dynamic interplay between Gnai3, Gpsm1, and Ccdc88a determines whether autophagy is promoted or inhibited. During starving conditions, Gpsm1 binds to Gnai3 in Map1lc3a-positive membranes to promote autophagy. When stimulated by growth factors, Ccdc88a promotes the dissociation of Gpsm1::Gnai3 complex to initiate anti-autophagy signaling pathways.

Entrez Gene

Summary

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:136327476-136359605

Strand

Forward strand

Band

q34.3

Transcripts

ENST00000354753	ENSP00000346797
ENST00000291775	ENSP00000291775
ENST00000392944	ENSP00000376673
ENST00000440944	ENSP00000392828
ENST00000429455	ENSP00000390705
ENST00000616132	ENSP00000479405

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005092	GDP-dissociation inhibitor activity
GO:0005515	protein binding
GO:0030695	GTPase regulator activity

Biological Process

GO:0007399	nervous system development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026930

View Gene Order

ENSBTAG00000018799

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.239370 Hs.595811

RefSeq

NM_001145638 NM_001145639 NM_001200003 NM_015597

HUGO

OMIM

CCDS

CCDS48055 CCDS48056 CCDS6996

HPRD

17075

IMGT

EMBL

GenPept

RNA Seq Atlas