Version 5.4
Homo sapiens Gene: VBP1
Summary
InnateDB Gene IDBG-92436.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VBP1
Gene Name von Hippel-Lindau binding protein 1
Synonyms PFD3; PFDN3; VBP-1
Species Homo sapiens
Ensembl Gene ENSG00000155959
Encoded Proteins
IDBP-92438
von Hippel-Lindau binding protein 1
IDBP-596991
von Hippel-Lindau binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. Because it functions as a chaperone protein, it is suspected that it may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. [provided by RefSeq, Jul 2008]
The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. Because it functions as a chaperone protein, it is suspected that it may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:155197007-155239817
Strand Forward strand
Band q28
Transcripts
ENST00000286428 ENSP00000286428
ENST00000460509
ENST00000535916 ENSP00000438694
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016272 prefoldin complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031197
View Gene Order
ENSBTAG00000017265
Not yet available
Pathways
NETPATH
REACTOME
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436803 Hs.633259 Hs.634015
RefSeq NM_003372
HUGO
OMIM
CCDS CCDS14765
HPRD 02135
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca