Version 5.4
Homo sapiens Gene: CAPZB
Summary
InnateDB Gene IDBG-92609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPZB
Gene Name capping protein (actin filament) muscle Z-line, beta
Synonyms CAPB; CAPPB; CAPZ
Species Homo sapiens
Ensembl Gene ENSG00000077549
Encoded Proteins
IDBP-92611
capping protein (actin filament) muscle Z-line, beta
IDBP-92615
capping protein (actin filament) muscle Z-line, beta
IDBP-92617
capping protein (actin filament) muscle Z-line, beta
IDBP-92619
capping protein (actin filament) muscle Z-line, beta
IDBP-373399
capping protein (actin filament) muscle Z-line, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Apr 2011]
This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:19338776-19485539
Strand Reverse strand
Band p36.13
Transcripts
ENST00000264203 ENSP00000264203
ENST00000375144 ENSP00000364286
ENST00000375142 ENSP00000364284
ENST00000264202 ENSP00000264202
ENST00000433834 ENSP00000401010
ENST00000457768
ENST00000459967
ENST00000489607
ENST00000482808
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0048487 beta-tubulin binding
GO:0051015 actin filament binding
Biological Process
GO:0006928 cellular component movement
GO:0007010 cytoskeleton organization
GO:0007596 blood coagulation
GO:0022604 regulation of cell morphogenesis
GO:0030030 cell projection organization
GO:0030032 lamellipodium assembly
GO:0030036 actin cytoskeleton organization
GO:0031115 negative regulation of microtubule polymerization
GO:0031175 neuron projection development
GO:0048747 muscle fiber development
GO:0051016 barbed-end actin filament capping
GO:0090036 regulation of protein kinase C signaling
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0008290 F-actin capping protein complex
GO:0014704 intercalated disc
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030018 Z disc
GO:0030027 lamellipodium
GO:0030863 cortical cytoskeleton
GO:0070062 extracellular vesicular exosome
GO:0071203 WASH complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028745
View Gene Order
ENSBTAG00000004554
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P47756
TrEMBL B1AK85 B1AK87 B1AK88 F6USW4 Q7L4N0
UniProt Splice Variant
Entrez Gene 832
UniGene Hs.432760
RefSeq NM_001206540 NM_001206541 NM_001282162 NM_004930 XM_006710938
HUGO HGNC:1491
OMIM 601572
CCDS CCDS41277 CCDS55579 CCDS72717 CCDS72718
HPRD
IMGT
EMBL AK125085 AL035413 AL359199 AL445163 BC008095 BC024601 BC107752 BC109241 BC109242 BT019470 BT019471 CH471134 U03271
GenPept AAA87395 AAH08095 AAH24601 AAI07753 AAI09242 AAI09243 AAV38277 AAV38278 BAG54137 CAH71392 CAH72124 CAI22231 EAW94888 EAW94890 EAW94891
RNA Seq Atlas 832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca