Version 5.4
Homo sapiens Gene: EME2
Summary
InnateDB Gene IDBG-9284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EME2
Gene Name essential meiotic endonuclease 1 homolog 2 (S. pombe)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197774
Encoded Proteins
IDBP-751527
IDBP-754281
IDBP-752720
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:1773207-1781708
Strand Forward strand
Band p13.3
Transcripts
ENST00000565326
ENST00000568449 ENSP00000457353
ENST00000561903 ENSP00000457966
ENST00000564182 ENSP00000456946
ENST00000561564
ENST00000570069
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073436
View Gene Order
ENSBTAG00000016553
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.7247 Hs.731950
RefSeq NM_001257370
HUGO
OMIM
CCDS CCDS58404
HPRD 16859
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca