Version 5.4
Homo sapiens Gene: CDA
Summary
InnateDB Gene IDBG-92905.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDA
Gene Name cytidine deaminase
Synonyms CDD
Species Homo sapiens
Ensembl Gene ENSG00000158825
Encoded Proteins
IDBP-92907
cytidine deaminase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:20588948-20618908
Strand Forward strand
Band p36.12
Transcripts
ENST00000375071 ENSP00000364212
ENST00000461985
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001882 nucleoside binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0007166 cell surface receptor signaling pathway
GO:0008655 pyrimidine-containing compound salvage
GO:0009972 cytidine deamination
GO:0019858 cytosine metabolic process
GO:0030308 negative regulation of cell growth
GO:0043097 pyrimidine nucleoside salvage
GO:0044281 small molecule metabolic process
GO:0045980 negative regulation of nucleotide metabolic process
GO:0051289 protein homotetramerization
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028755
View Gene Order
ENSBTAG00000006136
Not yet available
Pathways
NETPATH
REACTOME
REACT_655
Pyrimidine salvage reactions pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001785
HUGO
OMIM
CCDS CCDS210
HPRD 11744
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca