InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRIN1

Summary

InnateDB Gene

IDBG-93071.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIN1

Gene Name

glutamate receptor, ionotropic, N-methyl D-aspartate 1

Synonyms

GluN1; MRD8; NMDA1; NMDAR1; NR1

Species

Homo sapiens

Ensembl Gene

ENSG00000176884

Encoded Proteins

IDBP-93073

glutamate receptor, ionotropic, N-methyl D-aspartate 1

IDBP-93077

glutamate receptor, ionotropic, N-methyl D-aspartate 1

IDBP-93079

glutamate receptor, ionotropic, N-methyl D-aspartate 1

IDBP-93081

glutamate receptor, ionotropic, N-methyl D-aspartate 1

IDBP-93083

glutamate receptor, ionotropic, N-methyl D-aspartate 1

IDBP-93085

glutamate receptor, ionotropic, N-methyl D-aspartate 1

IDBP-93087

glutamate receptor, ionotropic, N-methyl D-aspartate 1

IDBP-93093

glutamate receptor, ionotropic, N-methyl D-aspartate 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:137138390-137168762

Strand

Forward strand

Band

q34.3

Transcripts

ENST00000371561	ENSP00000360616
ENST00000371559	ENSP00000360614
ENST00000371560	ENSP00000360615
ENST00000350902	ENSP00000316915
ENST00000371553	ENSP00000360608
ENST00000371550	ENSP00000360605
ENST00000371555	ENSP00000360610
ENST00000371546	ENSP00000360601
ENST00000471122
ENST00000485413
ENST00000460273
ENST00000473811
ENST00000462584

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005102	receptor binding
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0016594	glycine binding
GO:0016595	glutamate binding
GO:0019899	enzyme binding
GO:0022843	voltage-gated cation channel activity
GO:0035254	glutamate receptor binding
GO:0042165	neurotransmitter binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001661	conditioned taste aversion
GO:0001964	startle response
GO:0001967	suckling behavior
GO:0001975	response to amphetamine
GO:0006810	transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007268	synaptic transmission
GO:0007585	respiratory gaseous exchange
GO:0007611	learning or memory
GO:0007612	learning
GO:0007613	memory
GO:0007616	long-term memory
GO:0008306	associative learning
GO:0008344	adult locomotory behavior
GO:0008355	olfactory learning
GO:0008542	visual learning
GO:0010646	regulation of cell communication
GO:0010942	positive regulation of cell death
GO:0014070	response to organic cyclic compound
GO:0014075	response to amine
GO:0018964	propylene metabolic process
GO:0019233	sensory perception of pain
GO:0021586	pons maturation
GO:0021987	cerebral cortex development
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0035176	social behavior
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0043065	positive regulation of apoptotic process
GO:0043278	response to morphine
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043576	regulation of respiratory gaseous exchange
GO:0045471	response to ethanol
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048167	regulation of synaptic plasticity
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048511	rhythmic process
GO:0048814	regulation of dendrite morphogenesis
GO:0050770	regulation of axonogenesis
GO:0050905	neuromuscular process
GO:0051262	protein tetramerization
GO:0051592	response to calcium ion
GO:0051963	regulation of synapse assembly
GO:0055074	calcium ion homeostasis
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060134	prepulse inhibition
GO:0060179	male mating behavior
GO:0060992	response to fungicide
GO:0071287	cellular response to manganese ion
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008021	synaptic vesicle
GO:0009986	cell surface
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032590	dendrite membrane
GO:0043005	neuron projection
GO:0043083	synaptic cleft
GO:0043195	terminal bouton
GO:0043197	dendritic spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0097481	neuronal postsynaptic density