InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DOCK1

Summary

InnateDB Gene

IDBG-93118.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOCK1

Gene Name

dedicator of cytokinesis 1

Synonyms

ced5; DOCK180

Species

Homo sapiens

Ensembl Gene

ENSG00000150760

Encoded Proteins

IDBP-93120

dedicator of cytokinesis 1

IDBP-812971

dedicator of cytokinesis 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis. [provided by RefSeq, Jul 2008]
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:126905409-127452517

Strand

Forward strand

Band

q26.2

Transcripts

ENST00000280333	ENSP00000280333
ENST00000473861
ENST00000484400
ENST00000495574
ENST00000464466
ENST00000623213	ENSP00000485033

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005488	binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0017124	SH3 domain binding
GO:0020037	heme binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006911	phagocytosis, engulfment
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007229	integrin-mediated signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0016477	cell migration
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043547	positive regulation of GTPase activity
GO:0045087	innate immune response