Version 5.4
Homo sapiens Gene: PTPRE
Summary
InnateDB Gene IDBG-93141.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRE
Gene Name protein tyrosine phosphatase, receptor type, E
Synonyms HPTPE; PTPE; R-PTP-EPSILON
Species Homo sapiens
Ensembl Gene ENSG00000132334
Encoded Proteins
IDBP-93143
protein tyrosine phosphatase, receptor type, E
IDBP-93145
protein tyrosine phosphatase, receptor type, E
IDBP-386867
protein tyrosine phosphatase, receptor type, E
IDBP-386872
protein tyrosine phosphatase, receptor type, E
IDBP-810497
protein tyrosine phosphatase, receptor type, E
IDBP-810500
protein tyrosine phosphatase, receptor type, E
IDBP-810501
protein tyrosine phosphatase, receptor type, E
IDBP-810503
protein tyrosine phosphatase, receptor type, E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:127907061-128085855
Strand Forward strand
Band q26.2
Transcripts
ENST00000254667 ENSP00000254667
ENST00000306042 ENSP00000303350
ENST00000442830 ENSP00000410540
ENST00000455661 ENSP00000416939
ENST00000471218 ENSP00000474102
ENST00000467366 ENSP00000474830
ENST00000487428
ENST00000495530 ENSP00000475063
ENST00000479896 ENSP00000473761
ENST00000492479
ENST00000463727
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0016311 dephosphorylation
GO:0033003 regulation of mast cell activation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0046627 negative regulation of insulin receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041836
View Gene Order
ENSBTAG00000002435
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
il6_7pathway
IL6-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.127022
RefSeq NM_006504 NM_130435 XM_005252691 XM_005252692 XM_006717932
HUGO
OMIM
CCDS CCDS7657 CCDS7658
HPRD 02956
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca