InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: XRCC6

Summary

InnateDB Gene

IDBG-9323.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRCC6

Gene Name

X-ray repair complementing defective repair in Chinese hamster cells 6

Synonyms

CTC75; CTCBF; G22P1; KU70; ML8; TLAA

Species

Homo sapiens

Ensembl Gene

ENSG00000196419

Encoded Proteins

IDBP-9325

X-ray repair complementing defective repair in Chinese hamster cells 6

IDBP-9327

X-ray repair complementing defective repair in Chinese hamster cells 6

IDBP-293254

X-ray repair complementing defective repair in Chinese hamster cells 6

IDBP-293251

X-ray repair complementing defective repair in Chinese hamster cells 6

IDBP-293253

X-ray repair complementing defective repair in Chinese hamster cells 6

IDBP-378260

X-ray repair complementing defective repair in Chinese hamster cells 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24098118

Vaccinia virus protein C16 influences the immune response by binding to the XRCC6/XRCC5 (Ku70/80) complex thus blocking PRKDC-dependent DNA sensing in fibroblasts

Entrez Gene

Summary

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:41621119-41664048

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000359308	ENSP00000352257
ENST00000360079	ENSP00000353192
ENST00000402580	ENSP00000384941
ENST00000405878	ENSP00000384257
ENST00000405506	ENSP00000384082
ENST00000428575	ENSP00000403679
ENST00000464116
ENST00000478914

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 347 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	347 [view]
Protein-Protein	341 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0042162	telomeric DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0051575	5'-deoxyribose-5-phosphate lyase activity

Biological Process

GO:0000723	telomere maintenance
GO:0006266	DNA ligation
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006351	transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007420	brain development
GO:0010212	response to ionizing radiation
GO:0016032	viral process
GO:0032481	positive regulation of type I interferon production
GO:0032508	DNA duplex unwinding
GO:0033151	V(D)J recombination
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050769	positive regulation of neurogenesis
GO:0071475	cellular hyperosmotic salinity response
GO:0071481	cellular response to X-ray
GO:0075713	establishment of integrated proviral latency

Cellular Component

GO:0000783	nuclear telomere cap complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0043234	protein complex
GO:0043564	Ku70:Ku80 complex
GO:0070419	nonhomologous end joining complex