Version 5.4
Homo sapiens Gene: IGFALS
Summary
InnateDB Gene IDBG-9328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGFALS
Gene Name insulin-like growth factor binding protein, acid labile subunit
Synonyms ACLSD; ALS
Species Homo sapiens
Ensembl Gene ENSG00000099769
Encoded Proteins
IDBP-9330
insulin-like growth factor binding protein, acid labile subunit
IDBP-363757
insulin-like growth factor binding protein, acid labile subunit
IDBP-747692
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:1790413-1794971
Strand Reverse strand
Band p13.3
Transcripts
ENST00000215539 ENSP00000215539
ENST00000415638 ENSP00000416683
ENST00000568221 ENSP00000456923
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046070
View Gene Order
ENSBTAG00000033299
Not yet available
Pathways
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P35858
TrEMBL H3BSX8
UniProt Splice Variant
Entrez Gene 3483
UniGene Hs.839
RefSeq NM_001146006 NM_004970
HUGO HGNC:5468
OMIM 601489
CCDS CCDS10446 CCDS53982
HPRD
IMGT
EMBL AC012180 AF192554 AK303146 AL031724 M86826
GenPept AAA36047 AAF06774 BAG64250 CAC36078
RNA Seq Atlas 3483

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca