Version 5.4
Homo sapiens Gene: INPP5A
Summary
InnateDB Gene IDBG-93466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INPP5A
Gene Name inositol polyphosphate-5-phosphatase, 40kDa
Synonyms 5PTASE
Species Homo sapiens
Ensembl Gene ENSG00000068383
Encoded Proteins
IDBP-93472
inositol polyphosphate-5-phosphatase, 40kDa
IDBP-93476
inositol polyphosphate-5-phosphatase, 40kDa
IDBP-93478
inositol polyphosphate-5-phosphatase, 40kDa
IDBP-386978
inositol polyphosphate-5-phosphatase, 40kDa
IDBP-386981
inositol polyphosphate-5-phosphatase, 40kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:132537820-132783480
Strand Forward strand
Band q26.3
Transcripts
ENST00000342652 ENSP00000340707
ENST00000368594 ENSP00000357583
ENST00000368593 ENSP00000357582
ENST00000423490 ENSP00000390936
ENST00000445580 ENSP00000390749
ENST00000487614
ENST00000498337
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005515 protein binding
GO:0042731 PH domain binding
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
Biological Process
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0046856 phosphatidylinositol dephosphorylation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025477
View Gene Order
ENSBTAG00000009181
Not yet available
Pathways
NETPATH
REACTOME
REACT_150352
Synthesis of IP2, IP, and Ins in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL B1AP38
UniProt Splice Variant
Entrez Gene 3632
UniGene Hs.523360 Hs.715308
RefSeq NM_005539
HUGO HGNC:6076
OMIM 600106
CCDS CCDS7669
HPRD 02521
IMGT
EMBL AL356603 AL392043 AL451069
GenPept
RNA Seq Atlas 3632

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca