InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TTK

Summary

InnateDB Gene

IDBG-93500.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TTK

Gene Name

TTK protein kinase

Synonyms

CT96; ESK; MPH1; MPS1; MPS1L1; PYT

Species

Homo sapiens

Ensembl Gene

ENSG00000112742

Encoded Proteins

IDBP-93502

TTK protein kinase

IDBP-93504

TTK protein kinase

IDBP-482582

TTK protein kinase

IDBP-480720

TTK protein kinase

IDBP-474175

TTK protein kinase

IDBP-482879

TTK protein kinase

IDBP-476703

TTK protein kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:80003887-80042527

Strand

Forward strand

Band

q14.1

Transcripts

ENST00000369798	ENSP00000358813
ENST00000230510	ENSP00000230510
ENST00000430061
ENST00000509894	ENSP00000422936
ENST00000509313	ENSP00000421406
ENST00000502580	ENSP00000424851
ENST00000511260	ENSP00000421636
ENST00000504040	ENSP00000427483
ENST00000515751
ENST00000504590

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	29 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007051	spindle organization
GO:0007052	mitotic spindle organization
GO:0007093	mitotic cell cycle checkpoint
GO:0007094	mitotic spindle assembly checkpoint
GO:0008284	positive regulation of cell proliferation
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0051304	chromosome separation

Cellular Component

GO:0005819	spindle
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038379

View Gene Order

ENSBTAG00000005456

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04110

Cell cycle pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.169840

RefSeq

NM_001166691 NM_003318

HUGO

OMIM

CCDS

CCDS4993 CCDS55040

HPRD

04973

IMGT

EMBL

GenPept

RNA Seq Atlas