InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EHMT1

Summary

InnateDB Gene

IDBG-93549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EHMT1

Gene Name

euchromatic histone-lysine N-methyltransferase 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000181090

Encoded Proteins

IDBP-476572

euchromatic histone-lysine N-methyltransferase 1

IDBP-477969

euchromatic histone-lysine N-methyltransferase 1

IDBP-599055

euchromatic histone-lysine N-methyltransferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:137618992-137870016

Strand

Forward strand

Band

q34.3

Transcripts

ENST00000371394
ENST00000462484	ENSP00000417328
ENST00000460843	ENSP00000417980
ENST00000492232
ENST00000460486
ENST00000495657
ENST00000478940
ENST00000462942	ENSP00000436107
ENST00000465566
ENST00000493484
ENST00000482340
ENST00000486164
ENST00000488242
ENST00000483653
ENST00000494249
ENST00000475564
ENST00000472849
ENST00000475704

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	42 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)
GO:0046976	histone methyltransferase activity (H3-K27 specific)
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0009790	embryo development
GO:0016568	chromatin modification
GO:0016571	histone methylation
GO:0018026	peptidyl-lysine monomethylation
GO:0018027	peptidyl-lysine dimethylation
GO:0034968	histone lysine methylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051567	histone H3-K9 methylation
GO:0070734	histone H3-K27 methylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000036893

View Gene Order

ENSBTAG00000012148

Not yet available

Pathways

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169274

Cellular Senescence pathway

REACT_169168

Senescence-Associated Secretory Phenotype (SASP) pathway

KEGG

hsa00310

Lysine degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.495511 Hs.603381

RefSeq

NM_001145527 NM_024757 XM_005266105 XM_005266106 XM_005266107 XM_005266109 XM_005266110 XM_006717288

HUGO

OMIM

CCDS

CCDS56595 CCDS7050

HPRD

07383

IMGT

EMBL

GenPept

RNA Seq Atlas