Version 5.4
Homo sapiens Gene: VENTX
Summary
InnateDB Gene IDBG-93605.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VENTX
Gene Name VENT homeobox
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151650
Encoded Proteins
IDBP-93607
VENT homeobox
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21670496
VENTX plays a pivotal role in human macrophage terminal differentiation and proinflammatory function. VENTX is upregulated during monocyte to macrophage differentiation, and ablation of VENTX in monocytes profoundly impairs their differentiation to macrophages.
Entrez Gene
Summary This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:133237404-133241929
Strand Forward strand
Band q26.3
Transcripts
ENST00000325980 ENSP00000357556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Cross-References
SwissProt O95231
TrEMBL
UniProt Splice Variant
Entrez Gene 27287
UniGene Hs.125231
RefSeq NM_014468
HUGO HGNC:13639
OMIM 607158
CCDS CCDS7675
HPRD
IMGT
EMBL AF068006 AF288039 AL445199 BC108915 BC108916
GenPept AAC82375 AAI08916 AAI08917 AAK83043 CAI17343
RNA Seq Atlas 27287

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca