Version 5.4
Homo sapiens Gene: NHP2L1
Summary
InnateDB Gene IDBG-9368.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NHP2L1
Gene Name NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
Synonyms 15.5K; FA-1; FA1; NHPX; OTK27; SNRNP15-5; SNU13; SPAG12; SSFA1
Species Homo sapiens
Ensembl Gene ENSG00000100138
Encoded Proteins
IDBP-9370
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
IDBP-9372
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
IDBP-293249
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
IDBP-293239
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5\' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:41673930-41690504
Strand Reverse strand
Band q13.2
Transcripts
ENST00000355257 ENSP00000347401
ENST00000215956 ENSP00000215956
ENST00000402458 ENSP00000383989
ENST00000401959 ENSP00000383949
ENST00000463675
ENST00000488571
ENST00000469028
ENST00000469522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 121 experimentally validated interaction(s) in this database.
Experimentally validated
Total 121 [view]
Protein-Protein 120 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030515 snoRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0030529 ribonucleoprotein complex
GO:0031428 box C/D snoRNP complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1753
mRNA Splicing - Minor Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001003796 NM_005008 XM_005261620 XM_006724258
HUGO
OMIM
CCDS CCDS14022 CCDS33653
HPRD 03197
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca