Version 5.4
Homo sapiens Gene: ME1
Summary
InnateDB Gene IDBG-93796.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ME1
Gene Name malic enzyme 1, NADP(+)-dependent, cytosolic
Synonyms HUMNDME; MES
Species Homo sapiens
Ensembl Gene ENSG00000065833
Encoded Proteins
IDBP-93798
malic enzyme 1, NADP(+)-dependent, cytosolic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:83210389-83431071
Strand Reverse strand
Band q14.2
Transcripts
ENST00000369705 ENSP00000358719
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004470 malic enzyme activity
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
GO:0005515 protein binding
GO:0008948 oxaloacetate decarboxylase activity
GO:0009055 electron carrier activity
GO:0030145 manganese ion binding
GO:0043531 ADP binding
GO:0046872 metal ion binding
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006108 malate metabolic process
GO:0006741 NADP biosynthetic process
GO:0009725 response to hormone
GO:0009743 response to carbohydrate
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0051262 protein tetramerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032418
View Gene Order
ENSBTAG00000005681
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00620
Pyruvate metabolism pathway
hsa03320
PPAR signaling pathway pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Pyruvate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.21160 Hs.600913
RefSeq NM_002395
HUGO
OMIM
CCDS CCDS34492
HPRD 01102
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca