InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KDM1A

Summary

InnateDB Gene

IDBG-93808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM1A

Gene Name

lysine (K)-specific demethylase 1A

Synonyms

AOF2; BHC110; KDM1; LSD1

Species

Homo sapiens

Ensembl Gene

ENSG00000004487

Encoded Proteins

IDBP-93810

lysine (K)-specific demethylase 1A

IDBP-228833

lysine (K)-specific demethylase 1A

IDBP-808188

lysine (K)-specific demethylase 1A

IDBP-808189

lysine (K)-specific demethylase 1A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20798038

Lysine-specific demethylase 1 (KDM1) is part of a repressor complex, along with key components that include histone deacetylase 1 or 2, RE-1 silencing transcription factor (REST), and co-repressor of REST (RCOR1). The KDM1/HDAC/REST/RCOR1 repressor complex is a significant component of host innate immunity.

Entrez Gene

Summary

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:23019448-23083689

Strand

Forward strand

Band

p36.12

Transcripts

ENST00000356634	ENSP00000349049
ENST00000400181	ENSP00000383042
ENST00000481879
ENST00000465864	ENSP00000473297
ENST00000494920	ENSP00000473294
ENST00000602503

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 522 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	522 [view]
Protein-Protein	518 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016491	oxidoreductase activity
GO:0019899	enzyme binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0032451	demethylase activity
GO:0032452	histone demethylase activity
GO:0032453	histone demethylase activity (H3-K4 specific)
GO:0032454	histone demethylase activity (H3-K9 specific)
GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)
GO:0043426	MRF binding
GO:0044212	transcription regulatory region DNA binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006482	protein demethylation
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0010725	regulation of primitive erythrocyte differentiation
GO:0021983	pituitary gland development
GO:0030851	granulocyte differentiation
GO:0032091	negative regulation of protein binding
GO:0033169	histone H3-K9 demethylation
GO:0034720	histone H3-K4 demethylation
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087	innate immune response (InnateDB)
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046886	positive regulation of hormone biosynthetic process
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051572	negative regulation of histone H3-K4 methylation
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0055001	muscle cell development
GO:0055114	oxidation-reduction process
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000179	positive regulation of neural precursor cell proliferation
GO:2000648	positive regulation of stem cell proliferation