Version 5.4
Homo sapiens Gene: CYP2E1
Summary
InnateDB Gene IDBG-93837.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP2E1
Gene Name cytochrome P450, family 2, subfamily E, polypeptide 1
Synonyms CPE1; CYP2E; P450-J; P450C2E
Species Homo sapiens
Ensembl Gene ENSG00000130649
Encoded Proteins
IDBP-93839
cytochrome P450, family 2, subfamily E, polypeptide 1
IDBP-387168
cytochrome P450, family 2, subfamily E, polypeptide 1
IDBP-387171
cytochrome P450, family 2, subfamily E, polypeptide 1
IDBP-587648
cytochrome P450, family 2, subfamily E, polypeptide 1
IDBP-598043
cytochrome P450, family 2, subfamily E, polypeptide 1
IDBP-596143
cytochrome P450, family 2, subfamily E, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:133520406-133561220
Strand Forward strand
Band q26.3
Transcripts
ENST00000252945 ENSP00000252945
ENST00000368520
ENST00000418356 ENSP00000397299
ENST00000421586 ENSP00000412754
ENST00000477500
ENST00000480558
ENST00000463117 ENSP00000440689
ENST00000469258
ENST00000541261 ENSP00000437799
ENST00000541080 ENSP00000444958
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 16 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 oxygen binding
GO:0019899 enzyme binding
GO:0020037 heme binding
Biological Process
GO:0006641 triglyceride metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0010193 response to ozone
GO:0010243 response to organonitrogen compound
GO:0016098 monoterpenoid metabolic process
GO:0017144 drug metabolic process
GO:0042493 response to drug
GO:0044281 small molecule metabolic process
GO:0045471 response to ethanol
GO:0046483 heterocycle metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0000139 Golgi membrane
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0031227 intrinsic component of endoplasmic reticulum membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025479
View Gene Order
ENSBTAG00000018365
Not yet available
Pathways
NETPATH
REACTOME
REACT_13797
CYP2E1 reactions pathway
REACT_13543
Xenobiotics pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa00140
Steroid hormone biosynthesis pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.12907 Hs.644140
RefSeq NM_000773
HUGO
OMIM
CCDS CCDS7686
HPRD 11813
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca