InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL11

Summary

InnateDB Gene

IDBG-93976.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL11

Gene Name

ribosomal protein L11

Synonyms

DBA7; GIG34; L11

Species

Homo sapiens

Ensembl Gene

ENSG00000142676

Encoded Proteins

IDBP-93978

ribosomal protein L11

IDBP-374949

ribosomal protein L11

IDBP-374952

ribosomal protein L11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:23691779-23696425

Strand

Forward strand

Band

p36.11

Transcripts

ENST00000374550	ENSP00000363676
ENST00000458455	ENSP00000398888
ENST00000443624	ENSP00000390839
ENST00000467075
ENST00000482370

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 163 experimentally validated interaction(s) in this database.

Experimentally validated
Total	163 [view]
Protein-Protein	163 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006605	protein targeting
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0034504	protein localization to nucleus
GO:0042273	ribosomal large subunit biogenesis
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0070062	extracellular vesicular exosome