InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NT5E

Summary

InnateDB Gene

IDBG-93979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NT5E

Gene Name

5'-nucleotidase, ecto (CD73)

Synonyms

CALJA; CD73; E5NT; eN; eNT; NT; NT5; NTE

Species

Homo sapiens

Ensembl Gene

ENSG00000135318

Encoded Proteins

IDBP-93981

5'-nucleotidase, ecto (CD73)

IDBP-93983

5'-nucleotidase, ecto (CD73)

IDBP-93987

5'-nucleotidase, ecto (CD73)

IDBP-384895

5'-nucleotidase, ecto (CD73)

IDBP-384897

5'-nucleotidase, ecto (CD73)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:85449584-85495791

Strand

Forward strand

Band

q14.3

Transcripts

ENST00000257770	ENSP00000257770
ENST00000369651	ENSP00000358665
ENST00000369646	ENSP00000358660
ENST00000416334	ENSP00000414674
ENST00000437581	ENSP00000387630

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0008253	5'-nucleotidase activity
GO:0016787	hydrolase activity
GO:0016788	hydrolase activity, acting on ester bonds
GO:0046872	metal ion binding

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006195	purine nucleotide catabolic process
GO:0006196	AMP catabolic process
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006259	DNA metabolic process
GO:0009166	nucleotide catabolic process
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046086	adenosine biosynthetic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0050728	negative regulation of inflammatory response
GO:0055086	nucleobase-containing small molecule metabolic process