Version 5.4
Homo sapiens Gene: SRSF10
Summary
InnateDB Gene IDBG-94079.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRSF10
Gene Name serine/arginine-rich splicing factor 10
Synonyms FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13; SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2
Species Homo sapiens
Ensembl Gene ENSG00000188529
Encoded Proteins
IDBP-94083
serine/arginine-rich splicing factor 10
IDBP-94089
serine/arginine-rich splicing factor 10
IDBP-94091
serine/arginine-rich splicing factor 10
IDBP-94097
serine/arginine-rich splicing factor 10
IDBP-362722
serine/arginine-rich splicing factor 10
IDBP-484770
serine/arginine-rich splicing factor 10
IDBP-809291
serine/arginine-rich splicing factor 10
IDBP-478995
serine/arginine-rich splicing factor 10
IDBP-809300
serine/arginine-rich splicing factor 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. This gene has multiple pseudogenes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.[provided by RefSeq, Jul 2010]
This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:23964804-23980927
Strand Reverse strand
Band p36.11
Transcripts
ENST00000341154
ENST00000344989 ENSP00000342913
ENST00000374453 ENSP00000363577
ENST00000374452 ENSP00000363576
ENST00000338597
ENST00000343255 ENSP00000344149
ENST00000453840 ENSP00000388991
ENST00000484146 ENSP00000419813
ENST00000473858 ENSP00000473293
ENST00000492112 ENSP00000420195
ENST00000485841
ENST00000495785 ENSP00000473291
ENST00000473754
ENST00000497214
ENST00000485292
ENST00000469303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 63 [view]
Protein-Protein 63 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0050733 RS domain binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006355 regulation of transcription, DNA-templated
GO:0006376 mRNA splice site selection
GO:0006406 mRNA export from nucleus
GO:0016482 cytoplasmic transport
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028676
View Gene Order
ENSBTAG00000008072
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.3530 Hs.602683
RefSeq NM_001191005 NM_001191006 NM_001191007 NM_001191009 NM_001300936 NM_006625 NM_054016 XM_006710298 XM_006710299 XM_006710300
HUGO
OMIM
CCDS CCDS30629 CCDS30630 CCDS53280 CCDS53281 CCDS53282 CCDS53283 CCDS72728
HPRD 05562
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca