Version 5.4
Homo sapiens Gene: IL28RA
Summary
InnateDB Gene IDBG-94157.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL28RA
Gene Name interleukin 28 receptor, alpha (interferon, lambda receptor)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185436
Encoded Proteins
IDBP-94159
interleukin 28 receptor, alpha (interferon, lambda receptor)
IDBP-94161
interleukin 28 receptor, alpha (interferon, lambda receptor)
IDBP-94163
interleukin 28 receptor, alpha (interferon, lambda receptor)
IDBP-94165
interleukin 28 receptor, alpha (interferon, lambda receptor)
IDBP-94167
interleukin 28 receptor, alpha (interferon, lambda receptor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25431490
[Mus musculus] Il28ra (Ifnlr1), Stat1 and Irf3 are required for antibiotics to prevent persistent murine norovirus infection.
Entrez Gene
Summary The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:24154157-24187959
Strand Reverse strand
Band p36.11
Transcripts
ENST00000327535 ENSP00000327824
ENST00000327575 ENSP00000328994
ENST00000374421 ENSP00000363542
ENST00000374419 ENSP00000363540
ENST00000374418 ENSP00000363539
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0002385 mucosal immune response
GO:0008285 negative regulation of cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0034342 response to type III interferon
GO:0050691 regulation of defense response to virus by host
GO:0051607 defense response to virus
Cellular Component
GO:0016021 integral component of membrane
GO:0032002 interleukin-28 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062157
View Gene Order
ENSBTAG00000001101
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q8IU57
TrEMBL
UniProt Splice Variant
Entrez Gene 163702
UniGene Hs.221375 Hs.619077
RefSeq NM_173065 NM_170743 NM_173064 XM_006710394
HUGO HGNC:18584
OMIM 607404
CCDS CCDS250 CCDS248 CCDS249
HPRD 09589
IMGT
EMBL AF439325 AJ534330 AJ534331 AK160364 AL590683 AY129151 AY129152 AY129153 BC140872 CH471134
GenPept AAI40873 AAN28266 AAN28267 AAN28268 AAN63632 BAD18707 CAD58829 CAD58830 CAH70118 CAH70119 CAH70120 CAH70121 EAW95114 EAW95115 EAW95117 EAW95118
RNA Seq Atlas 163702

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca