Version 5.4
Homo sapiens Gene: RUNX3
Summary
InnateDB Gene IDBG-94257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RUNX3
Gene Name runt-related transcription factor 3
Synonyms AML2; CBFA3; PEBP2aC
Species Homo sapiens
Ensembl Gene ENSG00000020633
Encoded Proteins
IDBP-94259
runt-related transcription factor 3
IDBP-94261
runt-related transcription factor 3
IDBP-229486
runt-related transcription factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16164020
RUNX3 is capable of activating the CD11a gene promoter that directs CD11a/CD18 integrin expression as well as trans-activating the CD49d gene promoter. The leukocyte integrins CD11a/CD18 (LFA-1, alphaLbeta2) and CD49d (VLA-4, alpha4beta1, alpha4beta7) mediate leukocyte transendothelial migration during immune and inflammatory responses and provide co-stimulatory signals for the activation of T lymphocytes.
Entrez Gene
Summary This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5\'-PYGPYGGT-3\' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:24899511-24965121
Strand Reverse strand
Band p36.11
Transcripts
ENST00000308873 ENSP00000308051
ENST00000338888 ENSP00000343477
ENST00000399916 ENSP00000382800
ENST00000496967
ENST00000479341
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 46 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002062 chondrocyte differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007411 axon guidance
GO:0031069 hair follicle morphogenesis
GO:0031175 neuron projection development
GO:0032609 interferon-gamma production
GO:0045087 innate immune response (InnateDB)
GO:0045786 negative regulation of cell cycle
GO:0048469 cell maturation
GO:0048935 peripheral nervous system neuron development
GO:0050680 negative regulation of epithelial cell proliferation
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000070691
View Gene Order
ENSBTAG00000019800
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q13761
TrEMBL A0A024RAH4
UniProt Splice Variant
Entrez Gene 864
UniGene Hs.170019
RefSeq NM_001031680 NM_004350 XM_005246024
HUGO HGNC:10473
OMIM 600210
CCDS CCDS257 CCDS30633
HPRD
IMGT
EMBL AL023096 AL445471 BC013362 CH471134 U14520 X79550 Z35278
GenPept AAA86465 AAH13362 CAA18856 CAA56093 CAA84541 CAC42093 CAI20422 EAW95148 EAW95149
RNA Seq Atlas 864

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca