Homo sapiens Gene: UBE2J1
Summary
InnateDB Gene IDBG-94305.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2J1
Gene Name ubiquitin-conjugating enzyme E2, J1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198833
Encoded Proteins
ubiquitin-conjugating enzyme E2, J1, U
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:89326625-89352848
Strand Reverse strand
Band q15
Transcripts
ENST00000435041 ENSP00000451261
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0016567 protein ubiquitination
GO:0018279 protein N-linked glycosylation via asparagine
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
Ubiquitin mediated proteolysis pathway
Parkinson's disease pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q9Y385
TrEMBL
UniProt Splice Variant
Entrez Gene 51465
UniGene Hs.163776 Hs.600765 Hs.607439
RefSeq NM_016021
HUGO HGNC:17598
OMIM
CCDS CCDS5021
HPRD
IMGT
EMBL AF151039 AF151834 AF161502 AJ245898 AK223464 AK290574 AL138717 AL139804 BC013973 CH471051 U93243
GenPept AAD34071 AAF21505 AAF29117 AAF36125 AAH13973 BAD97184 BAF83263 CAB83212 CAH70228 CAI19635 EAW48555 EAW48556
RNA Seq Atlas 51465