Version 5.4
Homo sapiens Gene: EPHA7
Summary
InnateDB Gene IDBG-94407.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPHA7
Gene Name EPH receptor A7
Synonyms EHK-3; EHK3; EK11; HEK11
Species Homo sapiens
Ensembl Gene ENSG00000135333
Encoded Proteins
IDBP-94409
EPH receptor A7
IDBP-94411
EPH receptor A7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:93240020-93419547
Strand Reverse strand
Band q16.1
Transcripts
ENST00000369303 ENSP00000358309
ENST00000369297 ENSP00000358303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008046 axon guidance receptor activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0045499 chemorepellent activity
GO:0046875 ephrin receptor binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007420 brain development
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0022407 regulation of cell-cell adhesion
GO:0031290 retinal ganglion cell axon guidance
GO:0031952 regulation of protein autophosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0048013 ephrin receptor signaling pathway
GO:0048755 branching morphogenesis of a nerve
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050919 negative chemotaxis
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0030425 dendrite
GO:0031594 neuromuscular junction
GO:0043025 neuronal cell body
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028289
View Gene Order
ENSBTAG00000021420
Not yet available
Pathways
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt Q15375
TrEMBL
UniProt Splice Variant
Entrez Gene 2045
UniGene Hs.606792 Hs.73962
RefSeq NM_001288629 NM_001288630 NM_004440 XM_005248669 XM_006715369
HUGO HGNC:3390
OMIM 602190
CCDS CCDS5031 CCDS75494
HPRD
IMGT
EMBL AB209269 AK313529 AL121966 AL354857 AL591036 BC027940 BC126125 BC126151 BC143857 BC143858 CH471051 L36642
GenPept AAA74243 AAH27940 AAI26126 AAI26152 AAI43858 AAI43859 BAD92506 BAG36308 CAC19520 CAH72780 CAH73650 CAI19722 EAW48518
RNA Seq Atlas 2045

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca