Homo sapiens Gene: FUT9
Summary
InnateDB Gene IDBG-94447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUT9
Gene Name fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
Synonyms Fuc-TIX
Species Homo sapiens
Ensembl Gene ENSG00000172461
Encoded Proteins
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:96015984-96215612
Strand Forward strand
Band q16.1
Transcripts
ENST00000302103 ENSP00000302599
ENST00000483933
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008417 fucosyltransferase activity
GO:0046920 alpha-(1->3)-fucosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0007399 nervous system development
GO:0036065 fucosylation
GO:0042355 L-fucose catabolic process
Cellular Component
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Glycosphingolipid biosynthesis pathway
Glycosphingolipid biosynthesis pathway
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q9Y231
TrEMBL
UniProt Splice Variant
Entrez Gene 10690
UniGene Hs.49117
RefSeq NM_006581
HUGO HGNC:4020
OMIM 606865
CCDS CCDS5033
HPRD 06036
IMGT
EMBL AB023021 AJ238701 AL512406 BC036101
GenPept AAH36101 BAA81685 CAB41890 CAI14863
RNA Seq Atlas 10690