InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRIM63

Summary

InnateDB Gene

IDBG-94466.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM63

Gene Name

tripartite motif containing 63, E3 ubiquitin protein ligase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000158022

Encoded Proteins

IDBP-94468

tripartite motif containing 63

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23438823

TRIM63 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:26051304-26068436

Strand

Reverse strand

Band

p36.11

Transcripts

ENST00000374272	ENSP00000363390
ENST00000483052

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	128 [view]
Protein-Protein	128 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031432	titin binding
GO:0046872	metal ion binding

Biological Process

GO:0006936	muscle contraction
GO:0007165	signal transduction
GO:0010468	regulation of gene expression
GO:0014732	skeletal muscle atrophy
GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation
GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051384	response to glucocorticoid
GO:0070555	response to interleukin-1
GO:0071549	cellular response to dexamethasone stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0030018	Z disc
GO:0031430	M band
GO:0043292	contractile fiber

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028834

View Gene Order

ENSBTAG00000005085

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.279709

RefSeq

NM_032588

HUGO

OMIM

CCDS

CCDS273

HPRD

05843

IMGT

EMBL

GenPept

RNA Seq Atlas