Version 5.4
Homo sapiens Gene: DHDDS
Summary
InnateDB Gene IDBG-94642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHDDS
Gene Name dehydrodolichyl diphosphate synthase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117682
Encoded Proteins
IDBP-94646
dehydrodolichyl diphosphate synthase
IDBP-94654
dehydrodolichyl diphosphate synthase
IDBP-94660
dehydrodolichyl diphosphate synthase
IDBP-376532
dehydrodolichyl diphosphate synthase
IDBP-376536
dehydrodolichyl diphosphate synthase
IDBP-376537
dehydrodolichyl diphosphate synthase
IDBP-376540
dehydrodolichyl diphosphate synthase
IDBP-376541
dehydrodolichyl diphosphate synthase
IDBP-376545
dehydrodolichyl diphosphate synthase
IDBP-597899
dehydrodolichyl diphosphate synthase
IDBP-603615
dehydrodolichyl diphosphate synthase
IDBP-599963
dehydrodolichyl diphosphate synthase
IDBP-595692
dehydrodolichyl diphosphate synthase
IDBP-592120
dehydrodolichyl diphosphate synthase
IDBP-593155
dehydrodolichyl diphosphate synthase
IDBP-602475
dehydrodolichyl diphosphate synthase
IDBP-587134
dehydrodolichyl diphosphate synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:26432282-26471294
Strand Forward strand
Band p36.11
Transcripts
ENST00000236342 ENSP00000236342
ENST00000360009 ENSP00000353104
ENST00000374186
ENST00000374185 ENSP00000363300
ENST00000434391 ENSP00000403529
ENST00000436153 ENSP00000405604
ENST00000430232 ENSP00000397584
ENST00000427245 ENSP00000399177
ENST00000431933 ENSP00000399781
ENST00000416052 ENSP00000393961
ENST00000487944
ENST00000527611
ENST00000525682 ENSP00000434984
ENST00000526219 ENSP00000434219
ENST00000533087 ENSP00000436119
ENST00000531312 ENSP00000436764
ENST00000525165 ENSP00000434185
ENST00000525326 ENSP00000431407
ENST00000525546 ENSP00000433976
ENST00000528557
ENST00000526278
ENST00000529688
ENST00000530781 ENSP00000433491
ENST00000531955
ENST00000525410
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0006489 dolichyl diphosphate biosynthetic process
GO:0008152 metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000012117
View Gene Order
ENSBTAG00000003235
Not yet available
Pathways
NETPATH
REACTOME
REACT_22230
Synthesis of Dolichyl-phosphate pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.369385 Hs.739921
RefSeq NM_001243564 NM_001243565 NM_024887 NM_205861 XM_006710912 XM_006710913 XM_006710914 XM_006710916 XM_006710917 XM_006710918 XM_006710919 XM_006710920
HUGO
OMIM
CCDS CCDS281 CCDS282 CCDS57983 CCDS57984
HPRD 12183
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca