Version 5.4
Homo sapiens Gene: RPS6KA1
Summary
InnateDB Gene IDBG-94680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS6KA1
Gene Name ribosomal protein S6 kinase, 90kDa, polypeptide 1
Synonyms HU-1; MAPKAPK1A; RSK; RSK1
Species Homo sapiens
Ensembl Gene ENSG00000117676
Encoded Proteins
IDBP-94682
ribosomal protein S6 kinase, 90kDa, polypeptide 1
IDBP-94684
ribosomal protein S6 kinase, 90kDa, polypeptide 1
IDBP-94688
ribosomal protein S6 kinase, 90kDa, polypeptide 1
IDBP-98960
ribosomal protein S6 kinase, 90kDa, polypeptide 1
IDBP-294583
ribosomal protein S6 kinase, 90kDa, polypeptide 1
IDBP-376647
ribosomal protein S6 kinase, 90kDa, polypeptide 1
IDBP-596831
ribosomal protein S6 kinase, 90kDa, polypeptide 1
IDBP-599554
ribosomal protein S6 kinase, 90kDa, polypeptide 1
IDBP-584190
ribosomal protein S6 kinase, 90kDa, polypeptide 1
IDBP-592200
ribosomal protein S6 kinase, 90kDa, polypeptide 1
IDBP-588579
ribosomal protein S6 kinase, 90kDa, polypeptide 1
IDBP-590045
ribosomal protein S6 kinase, 90kDa, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:26529761-26575030
Strand Forward strand
Band p36.11
Transcripts
ENST00000374168 ENSP00000363283
ENST00000374166 ENSP00000363281
ENST00000374163 ENSP00000363278
ENST00000366866 ENSP00000355831
ENST00000403732 ENSP00000383967
ENST00000438977 ENSP00000403548
ENST00000474934
ENST00000488985
ENST00000525525 ENSP00000434616
ENST00000526040 ENSP00000436990
ENST00000524436
ENST00000526792 ENSP00000431651
ENST00000529454 ENSP00000433039
ENST00000530003 ENSP00000432281
ENST00000531113
ENST00000530607
ENST00000531382 ENSP00000435412
ENST00000525582
ENST00000527264
ENST00000530305
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 85 [view]
Protein-Protein 85 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0009103 lipopolysaccharide biosynthetic process
GO:0030307 positive regulation of cell growth
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035556 intracellular signal transduction
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043555 regulation of translation in response to stress
GO:0043620 regulation of DNA-dependent transcription in response to stress
GO:0045087 innate immune response
GO:0045597 positive regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
GO:2000491 positive regulation of hepatic stellate cell activation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003644
View Gene Order
ENSBTAG00000014447
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_12
BCR pathway
NetPath_17
IL5 pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_147
IL11 pathway
REACTOME
REACT_12599
ERK/MAPK targets pathway
REACT_12524
CREB phosphorylation pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_20510
RSK activation pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_6900
Immune System pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_169274
Cellular Senescence pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
lymphangiogenesis_pathway
VEGFR3 signaling in lymphatic endothelium
mtor_4pathway
mTOR signaling pathway
fgf_pathway
FGF signaling pathway
Cross-References
SwissProt
TrEMBL E9PMM7
UniProt Splice Variant
Entrez Gene 6195
UniGene Hs.149957
RefSeq NM_001006665 NM_002953 XM_005245966 XM_005245967
HUGO HGNC:10430
OMIM 601684
CCDS CCDS284 CCDS30649
HPRD 03402
IMGT
EMBL AL627313
GenPept
RNA Seq Atlas 6195

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca