InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC9A1

Summary

InnateDB Gene

IDBG-94809.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC9A1

Gene Name

solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1

Synonyms

APNH; NHE-1; NHE1; PPP1R143

Species

Homo sapiens

Ensembl Gene

ENSG00000090020

Encoded Proteins

IDBP-94813

solute carrier family 9 (sodium/hydrogen exchanger), member 1

IDBP-94815

solute carrier family 9 (sodium/hydrogen exchanger), member 1

IDBP-94817

solute carrier family 9 (sodium/hydrogen exchanger), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:27098815-27166981

Strand

Reverse strand

Band

p36.11

Transcripts

ENST00000374089
ENST00000263980	ENSP00000263980
ENST00000374086	ENSP00000363199
ENST00000374084	ENSP00000363197
ENST00000447808
ENST00000490329

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015299	solute:proton antiporter activity
GO:0015385	sodium:proton antiporter activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001101	response to acid
GO:0002026	regulation of the force of heart contraction
GO:0005975	carbohydrate metabolic process
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0006885	regulation of pH
GO:0010447	response to acidity
GO:0014070	response to organic cyclic compound
GO:0016049	cell growth
GO:0030154	cell differentiation
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0030307	positive regulation of cell growth
GO:0032869	cellular response to insulin stimulus
GO:0035725	sodium ion transmembrane transport
GO:0035794	positive regulation of mitochondrial membrane permeability
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0045760	positive regulation of action potential
GO:0051259	protein oligomerization
GO:0051453	regulation of intracellular pH
GO:0051930	regulation of sensory perception of pain
GO:0055007	cardiac muscle cell differentiation
GO:0055085	transmembrane transport
GO:0070997	neuron death
GO:0071236	cellular response to antibiotic
GO:0071257	cellular response to electrical stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071436	sodium ion export
GO:0071456	cellular response to hypoxia
GO:0071468	cellular response to acidity
GO:0086003	cardiac muscle cell contraction
GO:1902533	positive regulation of intracellular signal transduction
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome