InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRDM1

Summary

InnateDB Gene

IDBG-94825.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDM1

Gene Name

PR domain containing 1, with ZNF domain

Synonyms

BLIMP1; PRDI-BF1

Species

Homo sapiens

Ensembl Gene

ENSG00000057657

Encoded Proteins

IDBP-94829

PR domain containing 1, with ZNF domain

IDBP-94831

PR domain containing 1, with ZNF domain

IDBP-94833

PR domain containing 1, with ZNF domain

IDBP-385697

PR domain containing 1, with ZNF domain

IDBP-385699

PR domain containing 1, with ZNF domain

IDBP-808307

PR domain containing 1, with ZNF domain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24477914

[Mus musculus] Prdm1 (Blimp1) modulates host defences by suppressing Ccl8-induced inflammation.

Entrez Gene

Summary

This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:106086320-106109939

Strand

Forward strand

Band

q21

Transcripts

ENST00000369096	ENSP00000358092
ENST00000369091	ENSP00000358087
ENST00000369089	ENSP00000358085
ENST00000424894	ENSP00000395566
ENST00000450060	ENSP00000399772
ENST00000489365
ENST00000481163
ENST00000613999	ENSP00000478294

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	21 [view]
Protein-DNA	37 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001892	embryonic placenta development
GO:0001893	maternal placenta development
GO:0006351	transcription, DNA-templated
GO:0007281	germ cell development
GO:0009791	post-embryonic development
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0030889	negative regulation of B cell proliferation
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032259	methylation
GO:0042462	eye photoreceptor cell development
GO:0045165	cell fate commitment
GO:0045579	positive regulation of B cell differentiation
GO:0060576	intestinal epithelial cell development
GO:0060707	trophoblast giant cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038151

View Gene Order

ENSBTAG00000000816

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

B2REA5

UniProt Splice Variant

Entrez Gene

639

UniGene

Hs.436023

RefSeq

NM_001198 NM_182907 XM_005267094

HUGO

HGNC:9346

OMIM

603423

CCDS

CCDS34505 CCDS5054

HPRD

04572

IMGT

EMBL

AL022067 AL358952

GenPept

RNA Seq Atlas

639