Version 5.4
Homo sapiens Gene: MAP3K6
Summary
InnateDB Gene IDBG-94865.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP3K6
Gene Name mitogen-activated protein kinase kinase kinase 6
Synonyms ASK2; MAPKKK6; MEKK6
Species Homo sapiens
Ensembl Gene ENSG00000142733
Encoded Proteins
IDBP-94867
mitogen-activated protein kinase kinase kinase 6
IDBP-94871
mitogen-activated protein kinase kinase kinase 6
IDBP-484337
mitogen-activated protein kinase kinase kinase 6
IDBP-485169
mitogen-activated protein kinase kinase kinase 6
IDBP-483388
mitogen-activated protein kinase kinase kinase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:27355184-27366892
Strand Reverse strand
Band p36.11
Transcripts
ENST00000357582 ENSP00000350195
ENST00000374040 ENSP00000363152
ENST00000472410 ENSP00000418731
ENST00000486046 ENSP00000418932
ENST00000493901 ENSP00000419591
ENST00000470890
ENST00000476509
ENST00000495230
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007257 activation of JUN kinase activity
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028862
View Gene Order
ENSBTAG00000010254
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
p38_mkk3_6pathway
p38 MAPK signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.194694
RefSeq NM_001297609 NM_004672 XM_005246029
HUGO
OMIM
CCDS CCDS299 CCDS72738
HPRD 05126
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca