InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FCN3

Summary

InnateDB Gene

IDBG-94882.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCN3

Gene Name

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

Synonyms

FCNH; HAKA1

Species

Homo sapiens

Ensembl Gene

ENSG00000142748

Encoded Proteins

IDBP-94884

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

IDBP-94886

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20375620

FCN3, as well as ficolins FCN1 and FCN2, in serum are associated with MBL-associated serine protease (MASP) to form a complex and this complex binds to carbohydrates present on the surface of a variety of Gram-positive and Gram-negative bacteria through ficolin, initiating complement activation via the lectin pathway.

PMID 26133042

H-Ficolin (FCN3), an innate immune opsonin, participates in Aspergillus fumigatus defence through the activation of the lectin complement pathway, enhancement of fungus-host interactions and modulation of immune responses.

Entrez Gene

Summary

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:27369112-27374824

Strand

Reverse strand

Band

p36.11

Transcripts

ENST00000354982	ENSP00000347077
ENST00000270879	ENSP00000270879
ENST00000498393
ENST00000481748

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0001867	complement activation, lectin pathway
GO:0006956	complement activation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0072562	blood microparticle

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_7964

Lectin pathway of complement activation pathway

REACT_8024

Initial triggering of complement pathway

REACT_6802

Innate Immune System pathway

REACT_8012

Creation of C4 and C2 activators pathway

REACT_6900

Immune System pathway

REACT_163810

Ficolins bind to repetitive carbohydrate structures on the target cell surface pathway

REACT_6932

Complement cascade pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.627093

RefSeq

NM_003665 NM_173452

HUGO

OMIM

CCDS

CCDS300 CCDS301

HPRD

05399

IMGT

EMBL

GenPept

RNA Seq Atlas