Version 5.4
Homo sapiens Gene: FOXO3
Summary
InnateDB Gene IDBG-95024.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXO3
Gene Name forkhead box O3
Synonyms AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A
Species Homo sapiens
Ensembl Gene ENSG00000118689
Encoded Proteins
IDBP-95026
forkhead box O3
IDBP-293577
forkhead box O3
IDBP-596379
forkhead box O3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19050264
FOXO3 is a transcriptional activator which targets genes FAS ligand and TNFSF10 (TRAIL), involved in the extrinsic apoptotic pathway, and BBC3 (PUMA), PMAIP1 (Noxa), and BCL2L11 (Bim), which are part of the intrinsic apoptotic pathway.
PMID 20739833
FOXO3, along with AKT, is involved in TLR9-mediated anti-apoptosis and is a distinct regulator for FLICE-like inhibitory protein (FLIP) expression.
PMID 22531926
FOXO3 is an IKBKE-controlled checkpoint of IRF activation and regulation of IFNB expression.
PMID 22982991
OXO3 is a negative regulator of IRF7 transcription, and forms a coherent feed-forward regulatory circuit with IRF7 and IFNB to maximize antiviral responses. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22531926
[Mus musculus] Foxo3 is an Ikbke-controlled checkpoint of IRF activation and regulation of Ifnb expression. (Demonstrated in human)
PMID 22982991
[Mus musculus] FOXO3 is a negative regulator of Irf7 transcription, and forms a coherent feed-forward regulatory circuit with Irf7 and Ifnb to maximize antiviral responses.
Entrez Gene
Summary This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:108559835-108684774
Strand Forward strand
Band q21
Transcripts
ENST00000343882 ENSP00000339527
ENST00000406360 ENSP00000385824
ENST00000540898 ENSP00000446316
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 87 [view]
Protein-Protein 75 [view]
Protein-DNA 11 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0001221 transcription cofactor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001542 ovulation from ovarian follicle
GO:0001544 initiation of primordial ovarian follicle growth
GO:0001547 antral ovarian follicle growth
GO:0001556 oocyte maturation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006417 regulation of translation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0034599 cellular response to oxidative stress
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042593 glucose homeostasis
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048756
View Gene Order
ENSBTAG00000011234
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_19
IL-7 pathway
NetPath_24
TSLP pathway
NetPath_25
FSH pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_12442
AKT phosphorylates targets in the nucleus pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_111057
Signaling by NODAL pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa05213
Endometrial cancer pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
pi3kcipathway
Class I PI3K signaling events
myc_represspathway
Validated targets of C-MYC transcriptional repression
foxopathway
FoxO family signaling
p73pathway
p73 transcription factor network
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
il2_pi3kpathway
IL2 signaling events mediated by PI3K
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.220950 Hs.592126
RefSeq NM_001455 NM_201559 XM_005266867 XM_005266868
HUGO
OMIM
CCDS CCDS5068
HPRD 04061
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca