Version 5.4
Homo sapiens Gene: SMPDL3B
Summary
InnateDB Gene IDBG-95108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMPDL3B
Gene Name sphingomyelin phosphodiesterase, acid-like 3B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130768
Encoded Proteins
IDBP-95110
sphingomyelin phosphodiesterase, acid-like 3B
IDBP-95114
sphingomyelin phosphodiesterase, acid-like 3B
IDBP-377290
sphingomyelin phosphodiesterase, acid-like 3B
IDBP-597976
sphingomyelin phosphodiesterase, acid-like 3B
IDBP-601165
sphingomyelin phosphodiesterase, acid-like 3B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26095358
[Mus musculus] The membrane-modulating enzyme SMPDL3B is a negative regulator of TLR signalling that functions at the interface of membrane biology and innate immunity.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:27934993-27959157
Strand Forward strand
Band p35.3
Transcripts
ENST00000373894 ENSP00000363001
ENST00000373888 ENSP00000362995
ENST00000411604 ENSP00000388092
ENST00000466793
ENST00000548116 ENSP00000449057
ENST00000549094 ENSP00000449450
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006685 sphingomyelin catabolic process
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028885
View Gene Order
ENSBTAG00000012997
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.123659
RefSeq NM_001009568 NM_014474
HUGO
OMIM
CCDS CCDS30655 CCDS30656
HPRD 15405
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca