Version 5.4
Homo sapiens Gene: DDO
Summary
InnateDB Gene IDBG-95243.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDO
Gene Name D-aspartate oxidase
Synonyms DASOX; DDO-1; DDO-2
Species Homo sapiens
Ensembl Gene ENSG00000203797
Encoded Proteins
IDBP-95247
D-aspartate oxidase
IDBP-95249
D-aspartate oxidase
IDBP-592071
D-aspartate oxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:110391771-110415562
Strand Reverse strand
Band q21
Transcripts
ENST00000368924 ENSP00000357920
ENST00000368923 ENSP00000357919
ENST00000479373 ENSP00000436642
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008445 D-aspartate oxidase activity
GO:0016491 oxidoreductase activity
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0048037 cofactor binding
Biological Process
GO:0006531 aspartate metabolic process
GO:0006533 aspartate catabolic process
GO:0007320 insemination
GO:0007625 grooming behavior
GO:0019478 D-amino acid catabolic process
GO:0042445 hormone metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005777 peroxisome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063428
View Gene Order
ENSBTAG00000033367
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00250
Alanine, aspartate and glutamate metabolism pathway
hsa04146
Peroxisome pathway
INOH
INOH website
Alanine Aspartate Asparagine metabolism pathway
PID NCI
Cross-References
SwissProt Q99489
TrEMBL
UniProt Splice Variant
Entrez Gene 8528
UniGene Hs.195313 Hs.591348
RefSeq NM_004032 NM_003649
HUGO HGNC:2727
OMIM 124450
CCDS CCDS5083 CCDS5082
HPRD 00498
IMGT
EMBL AK293029 AL050350 BC032786 CH471051 D89858 DN990727
GenPept AAH32786 BAA14031 BAF85718 CAI42509 CAI42510 CAI42511 EAW48316 EAW48317
RNA Seq Atlas 8528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca