InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AMD1

Summary

InnateDB Gene

IDBG-95287.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMD1

Gene Name

adenosylmethionine decarboxylase 1

Synonyms

ADOMETDC; AMD; SAMDC

Species

Homo sapiens

Ensembl Gene

ENSG00000123505

Encoded Proteins

IDBP-95289

adenosylmethionine decarboxylase 1

IDBP-95291

adenosylmethionine decarboxylase 1

IDBP-95293

adenosylmethionine decarboxylase 1

IDBP-95295

adenosylmethionine decarboxylase 1

IDBP-386067

adenosylmethionine decarboxylase 1

IDBP-603600

adenosylmethionine decarboxylase 1

IDBP-807174

adenosylmethionine decarboxylase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Two alternatively spliced transcript variants that encode different proteins have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y.[provided by RefSeq, Jul 2010]
This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:110814621-110895713

Strand

Forward strand

Band

q21

Transcripts

ENST00000368885	ENSP00000357880
ENST00000368882	ENSP00000357877
ENST00000368877	ENSP00000357871
ENST00000368876	ENSP00000357870
ENST00000451850	ENSP00000389988
ENST00000465404	ENSP00000433396
ENST00000612642
ENST00000619590
ENST00000610605	ENSP00000483984

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004014	adenosylmethionine decarboxylase activity
GO:0019810	putrescine binding

Biological Process

GO:0006557	S-adenosylmethioninamine biosynthetic process
GO:0006595	polyamine metabolic process
GO:0006597	spermine biosynthetic process
GO:0008295	spermidine biosynthetic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046500	S-adenosylmethionine metabolic process

Cellular Component

GO:0005829

cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000075232

View Gene Order

ENSBTAG00000003342

Not yet available

Pathways

NETPATH

REACTOME

REACT_14820

Metabolism of polyamines pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00330

Arginine and proline metabolism pathway

hsa00270

Cysteine and methionine metabolism pathway

INOH

INOH website

Arginine Proline metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001287214 NM_001287215 NM_001287216 NM_001634

HUGO

OMIM

CCDS

CCDS5086 CCDS75504 CCDS75505

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas