Version 5.4
Homo sapiens Gene: PTPRU
Summary
InnateDB Gene IDBG-95340.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRU
Gene Name protein tyrosine phosphatase, receptor type, U
Synonyms FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI; PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U
Species Homo sapiens
Ensembl Gene ENSG00000060656
Encoded Proteins
IDBP-95342
protein tyrosine phosphatase, receptor type, U
IDBP-95344
protein tyrosine phosphatase, receptor type, U
IDBP-377921
protein tyrosine phosphatase, receptor type, U
IDBP-589013
protein tyrosine phosphatase, receptor type, U
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:29236516-29326813
Strand Forward strand
Band p35.3
Transcripts
ENST00000373779 ENSP00000362884
ENST00000345512 ENSP00000334941
ENST00000428026 ENSP00000392332
ENST00000415600
ENST00000460170 ENSP00000432906
ENST00000493601
ENST00000465525
ENST00000492954
ENST00000527027
ENST00000531385
ENST00000526080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0007155 cell adhesion
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0016311 dephosphorylation
GO:0016337 single organismal cell-cell adhesion
GO:0030154 cell differentiation
GO:0030336 negative regulation of cell migration
GO:0031100 organ regeneration
GO:0034109 homotypic cell-cell adhesion
GO:0034394 protein localization to cell surface
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0051384 response to glucocorticoid
GO:0060070 canonical Wnt signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028909
View Gene Order
ENSBTAG00000012848
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
REACT_111040
Signaling by SCF-KIT pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q92729
TrEMBL B3KT29
UniProt Splice Variant
Entrez Gene 10076
UniGene Hs.19718
RefSeq NM_001195001 XM_006710270 NM_005704 NM_133177 NM_133178 XM_006710269 XM_006710272 XM_006710273
HUGO HGNC:9683
OMIM 602454
CCDS CCDS53290 CCDS334 CCDS335 CCDS44098
HPRD 03908
IMGT
EMBL AB208855 AK094849 AL049570 AL590729 AL645859 BC146655 CH471059 U60289 U71075 U73727 X95712 X97198
GenPept AAB07074 AAB51343 AAC51938 AAI46656 BAD92092 BAG52941 CAA65016 CAA65832 CAH72393 CAH72394 CAI14331 CAI14332 CAI20946 CAI20947 EAX07651 EAX07652
RNA Seq Atlas 10076

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca