Version 5.4
Homo sapiens Gene: FYN
Summary
InnateDB Gene IDBG-95463.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FYN
Gene Name FYN oncogene related to SRC, FGR, YES
Synonyms p59-FYN; SLK; SYN
Species Homo sapiens
Ensembl Gene ENSG00000010810
Encoded Proteins
IDBP-95465
FYN oncogene related to SRC, FGR, YES
IDBP-95467
FYN oncogene related to SRC, FGR, YES
IDBP-95471
FYN oncogene related to SRC, FGR, YES
IDBP-95475
FYN oncogene related to SRC, FGR, YES
IDBP-95477
FYN oncogene related to SRC, FGR, YES
IDBP-484403
FYN oncogene related to SRC, FGR, YES
IDBP-483739
FYN oncogene related to SRC, FGR, YES
IDBP-474246
FYN oncogene related to SRC, FGR, YES
IDBP-480431
FYN oncogene related to SRC, FGR, YES
IDBP-476406
FYN oncogene related to SRC, FGR, YES
IDBP-482073
FYN oncogene related to SRC, FGR, YES
IDBP-479995
FYN oncogene related to SRC, FGR, YES
IDBP-478692
FYN oncogene related to SRC, FGR, YES
IDBP-477052
FYN oncogene related to SRC, FGR, YES
IDBP-474095
FYN oncogene related to SRC, FGR, YES
IDBP-480406
FYN oncogene related to SRC, FGR, YES
IDBP-480547
FYN oncogene related to SRC, FGR, YES
IDBP-474584
FYN oncogene related to SRC, FGR, YES
IDBP-584112
FYN oncogene related to SRC, FGR, YES
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:111660332-111873452
Strand Reverse strand
Band q21
Transcripts
ENST00000368682 ENSP00000357671
ENST00000368678 ENSP00000357667
ENST00000229471 ENSP00000229471
ENST00000368667 ENSP00000357656
ENST00000354650 ENSP00000346671
ENST00000491885
ENST00000467921
ENST00000471959
ENST00000496864
ENST00000476769
ENST00000495935
ENST00000467899
ENST00000495927
ENST00000523322
ENST00000462856 ENSP00000427993
ENST00000520518 ENSP00000429294
ENST00000517419 ENSP00000429866
ENST00000518295 ENSP00000428695
ENST00000523238 ENSP00000430364
ENST00000524310 ENSP00000428493
ENST00000523574 ENSP00000429992
ENST00000462598 ENSP00000429590
ENST00000518630 ENSP00000429813
ENST00000523570 ENSP00000428045
ENST00000484067 ENSP00000428983
ENST00000521062 ENSP00000428042
ENST00000521361
ENST00000487824 ENSP00000430455
ENST00000538466 ENSP00000440646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 253 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 253 [view]
Protein-Protein 252 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0001948 glycoprotein binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015631 tubulin binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0032403 protein complex binding
GO:0042608 T cell receptor binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044325 ion channel binding
GO:0046872 metal ion binding
GO:0046875 ephrin receptor binding
GO:0051428 peptide hormone receptor binding
GO:0070851 growth factor receptor binding
Biological Process
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0007166 cell surface receptor signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0007612 learning
GO:0007631 feeding behavior
GO:0008360 regulation of cell shape
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010629 negative regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032 viral process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030168 platelet activation
GO:0030900 forebrain development
GO:0031295 T cell costimulation
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042177 negative regulation of protein catabolic process
GO:0042493 response to drug
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response
GO:0045471 response to ethanol
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048813 dendrite morphogenesis
GO:0050690 regulation of defense response to virus by virus
GO:0050798 activated T cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0071363 cellular response to growth factor stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:1900182 positive regulation of protein localization to nucleus
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019843
View Gene Order
ENSBTAG00000011851
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_18
IL6 pathway
NetPath_19
IL-7 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_24
TSLP pathway
NetPath_25
FSH pathway
NetPath_56
Prolactin pathway
NetPath_147
IL11 pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160274
FCGR activation pathway
REACT_23787
Regulation of signaling by CBL pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_19405
CTLA4 inhibitory signaling pathway
REACT_19358
CD28 dependent PI3K/Akt signaling pathway
REACT_19238
CD28 dependent Vav1 pathway pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_12519
PECAM1 interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1230
Platelet Adhesion to exposed collagen pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111225
Regulation of KIT signaling pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_11068
Nef and signal transduction pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_23832
Nephrin interactions pathway
REACT_22384
Netrin mediated repulsion signals pathway
REACT_22351
DCC mediated attractive signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_19199
CRMPs in Sema3A signaling pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_19279
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_111155
Cell-Cell communication pathway
REACT_19271
Semaphorin interactions pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_12529
Signaling by VEGF pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228226
Ephrin signaling pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_22232
Signaling by Interleukins pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_6185
HIV Infection pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04520
Adherens junction pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05020
Prion diseases pathway
hsa05416
Viral myocarditis pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
il2_1pathway
IL2-mediated signaling events
reelinpathway
Reelin signaling pathway
netrin_pathway
Netrin-mediated signaling events
erbb4_pathway
ErbB4 signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
ephrinarevpathway
Ephrin A reverse signaling
syndecan_3_pathway
Syndecan-3-mediated signaling events
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.623374
RefSeq NM_002037 NM_153047 NM_153048 XM_005266887 XM_005266888 XM_005266889 XM_005266890 XM_005266892 XM_006715429 XM_006715626
HUGO
OMIM
CCDS CCDS5094 CCDS5095 CCDS5096
HPRD 00655
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca