InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KHDRBS1

Summary

InnateDB Gene

IDBG-95540.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KHDRBS1

Gene Name

KH domain containing, RNA binding, signal transduction associated 1

Synonyms

p62; p68; Sam68

Species

Homo sapiens

Ensembl Gene

ENSG00000121774

Encoded Proteins

IDBP-95542

KH domain containing, RNA binding, signal transduction associated 1

IDBP-479623

KH domain containing, RNA binding, signal transduction associated 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3\'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:32013829-32060850

Strand

Forward strand

Band

p35.2

Transcripts

ENST00000327300	ENSP00000313829
ENST00000307714
ENST00000484270
ENST00000492989	ENSP00000417731

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 198 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	198 [view]
Protein-Protein	192 [view]
Protein-DNA	3 [view]
Protein-RNA	2 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0008143	poly(A) binding
GO:0008266	poly(U) RNA binding
GO:0017124	SH3 domain binding
GO:0032403	protein complex binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006397	mRNA processing
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0008283	cell proliferation
GO:0009967	positive regulation of signal transduction
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045948	positive regulation of translational initiation
GO:0046831	regulation of RNA export from nucleus
GO:0046833	positive regulation of RNA export from nucleus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070618	Grb2-Sos complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028790

View Gene Order

ENSBTAG00000012497

Not yet available

Pathways

NETPATH

EGFR1 pathway

TCR pathway

Leptin pathway

Prolactin pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q07666

TrEMBL

UniProt Splice Variant

Entrez Gene

10657

UniGene

Hs.445893 Hs.732508

RefSeq

NM_001271878 NM_006559

HUGO

HGNC:18116

OMIM

602489

CCDS

CCDS60067 CCDS350

HPRD

03926

IMGT

EMBL

AK091346 AL139249 AL445248 BC000717 BC010132 BC019109 CH471059 M88108 U78971

GenPept

AAA59990 AAB47504 AAH00717 AAH10132 AAH19109 BAC03643 CAH71944 CAH71945 CAI21971 CAI21972 EAX07576 EAX07577

RNA Seq Atlas

10657