InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HDAC2

Summary

InnateDB Gene

IDBG-95591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC2

Gene Name

histone deacetylase 2

Synonyms

HD2; RPD3; YAF1

Species

Homo sapiens

Ensembl Gene

ENSG00000196591

Encoded Proteins

IDBP-95593

histone deacetylase 2

IDBP-386286

histone deacetylase 2

IDBP-479055

histone deacetylase 2

IDBP-480000

histone deacetylase 2

IDBP-473728

histone deacetylase 2

IDBP-474280

histone deacetylase 2

IDBP-473662

histone deacetylase 2

IDBP-483004

histone deacetylase 2

IDBP-477206

histone deacetylase 2

IDBP-474327

histone deacetylase 2

IDBP-478309

histone deacetylase 2

IDBP-476949

histone deacetylase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20798038

Histone deacetylase 2 (HDAC2) is part of a repressor complex, along with key components that include HDAC1, RE-1 silencing transcription factor (REST), co-repressor of REST (CoREST), and lysine-specific demethylase (LSD) 1. The HDAC/CoREST/REST/LSD1 repressor complex is a significant component of host innate immunity.

PMID 26287468

TET2 selectively mediates active repression of IL6 transcription via NFKBIZ and HDAC2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 26287468

[Mus musculus] Tet2 selectively mediates active repression of Il6 transcription via Nfkbiz and Hdac2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.

Entrez Gene

Summary

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:113933028-114011308

Strand

Reverse strand

Band

q21

Transcripts

ENST00000368632	ENSP00000357621
ENST00000425835	ENSP00000417026
ENST00000519065	ENSP00000430432
ENST00000523334
ENST00000519108	ENSP00000430008
ENST00000520746
ENST00000518756
ENST00000523628	ENSP00000427861
ENST00000521610	ENSP00000429901
ENST00000522371	ENSP00000428599
ENST00000521163	ENSP00000428024
ENST00000518690	ENSP00000428653
ENST00000523240	ENSP00000429236
ENST00000521233
ENST00000520895	ENSP00000428861
ENST00000524334	ENSP00000428989
ENST00000520170

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 502 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Experimentally validated
Total	502 [view]
Protein-Protein	391 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	102 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019213	deacetylase activity
GO:0019899	enzyme binding
GO:0031072	heat shock protein binding
GO:0031490	chromatin DNA binding
GO:0031492	nucleosomal DNA binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558	protein deacetylase activity
GO:0035851	Krueppel-associated box domain binding
GO:0043565	sequence-specific DNA binding
GO:0044822	poly(A) RNA binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006338	chromatin remodeling
GO:0006344	maintenance of chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0006476	protein deacetylation
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0009913	epidermal cell differentiation
GO:0010870	positive regulation of receptor biosynthetic process
GO:0010977	negative regulation of neuron projection development
GO:0016358	dendrite development
GO:0016575	histone deacetylation
GO:0021766	hippocampus development
GO:0030182	neuron differentiation
GO:0032922	circadian regulation of gene expression
GO:0032967	positive regulation of collagen biosynthetic process
GO:0034605	cellular response to heat
GO:0042220	response to cocaine
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042493	response to drug
GO:0042733	embryonic digit morphogenesis
GO:0043044	ATP-dependent chromatin remodeling
GO:0043066	negative regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0045347	negative regulation of MHC class II biosynthetic process
GO:0045786	negative regulation of cell cycle
GO:0045862	positive regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051896	regulation of protein kinase B signaling
GO:0055013	cardiac muscle cell development
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0060297	regulation of sarcomere organization
GO:0060789	hair follicle placode formation
GO:0061029	eyelid development in camera-type eye
GO:0061198	fungiform papilla formation
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090311	regulation of protein deacetylation
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005657	replication fork
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0016580	Sin3 complex
GO:0016581	NuRD complex
GO:0017053	transcriptional repressor complex
GO:0035098	ESC/E(Z) complex
GO:0043234	protein complex