Version 5.4
Homo sapiens Gene: RBBP4
Summary
InnateDB Gene IDBG-95780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBBP4
Gene Name retinoblastoma binding protein 4
Synonyms lin-53; NURF55; RBAP48
Species Homo sapiens
Ensembl Gene ENSG00000162521
Encoded Proteins
IDBP-95782
retinoblastoma binding protein 4
IDBP-95784
retinoblastoma binding protein 4
IDBP-379046
retinoblastoma binding protein 4
IDBP-379049
retinoblastoma binding protein 4
IDBP-379050
retinoblastoma binding protein 4
IDBP-596419
retinoblastoma binding protein 4
IDBP-596468
retinoblastoma binding protein 4
IDBP-600227
retinoblastoma binding protein 4
IDBP-603570
retinoblastoma binding protein 4
IDBP-583819
retinoblastoma binding protein 4
IDBP-591460
retinoblastoma binding protein 4
IDBP-596791
retinoblastoma binding protein 4
IDBP-595712
retinoblastoma binding protein 4
IDBP-586949
retinoblastoma binding protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:32651142-32686211
Strand Forward strand
Band p35.1
Transcripts
ENST00000373493 ENSP00000362592
ENST00000373485 ENSP00000362584
ENST00000401893
ENST00000414241 ENSP00000398242
ENST00000458695 ENSP00000396057
ENST00000445722 ENSP00000389437
ENST00000465780
ENST00000477563 ENSP00000432774
ENST00000490500 ENSP00000437210
ENST00000475321 ENSP00000436986
ENST00000492348 ENSP00000436663
ENST00000463378 ENSP00000433805
ENST00000460669 ENSP00000432298
ENST00000482190 ENSP00000436565
ENST00000527118 ENSP00000432780
ENST00000524393
ENST00000526193 ENSP00000434925
ENST00000525506
ENST00000531983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 216 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 216 [view]
Protein-Protein 214 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0005515 protein binding
GO:0008094 DNA-dependent ATPase activity
GO:0031492 nucleosomal DNA binding
GO:0042393 histone binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0031497 chromatin assembly
GO:0034080 centromere-specific nucleosome assembly
GO:0043044 ATP-dependent chromatin remodeling
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0016589 NURF complex
GO:0033186 CAF-1 complex
GO:0035098 ESC/E(Z) complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057236
View Gene Order
ENSBTAG00000005904
Not yet available
Pathways
NETPATH
REACTOME
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_111214
G0 and Early G1 pathway
REACT_1006
Polo-like kinase mediated events pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_120956
Cellular responses to stress pathway
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_115566
Cell Cycle pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_169274
Cellular Senescence pathway
REACT_172623
Chromatin organization pathway
REACT_2203
G2/M Transition pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
hdac_classi_pathway
Signaling events mediated by HDAC Class I
e2f_pathway
E2F transcription factor network
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.16003
RefSeq NM_001135255 NM_001135256 NM_005610
HUGO
OMIM
CCDS CCDS366 CCDS44105 CCDS44106
HPRD 04232
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca