Version 5.4
Homo sapiens Gene: MCM9
Summary
InnateDB Gene IDBG-95904.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCM9
Gene Name minichromosome maintenance complex component 9
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111877
Encoded Proteins
IDBP-95903
minichromosome maintenance complex component 9
IDBP-95910
minichromosome maintenance complex component 9
IDBP-386423
minichromosome maintenance complex component 9
IDBP-386435
minichromosome maintenance complex component 9
IDBP-475983
minichromosome maintenance complex component 9
IDBP-811639
minichromosome maintenance complex component 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:118813442-118935162
Strand Reverse strand
Band q22.31
Transcripts
ENST00000316316 ENSP00000314505
ENST00000316068 ENSP00000312870
ENST00000368478
ENST00000458674 ENSP00000406576
ENST00000436788
ENST00000425154 ENSP00000394776
ENST00000505485
ENST00000505446 ENSP00000426890
ENST00000619706 ENSP00000480469
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016851 magnesium chelatase activity
GO:0016887 ATPase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006974 cellular response to DNA damage stimulus
GO:0007276 gamete generation
GO:0007292 female gamete generation
GO:0015979 photosynthesis
GO:0015995 chlorophyll biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0097362 MCM8-MCM9 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058298
View Gene Order
ENSBTAG00000002059
Not yet available
Cross-References
SwissProt Q9NXL9
TrEMBL D6RE85 D6RHY8
UniProt Splice Variant
Entrez Gene 254394
UniGene Hs.279008 Hs.733116 Hs.735825 Hs.736853
RefSeq NM_017696 NM_153255
HUGO HGNC:21484
OMIM 610098
CCDS CCDS5121 CCDS56447
HPRD
IMGT
EMBL ABBA01026024 AK000177 AK299076 AL132874 AL359634 BC031658 BN000882
GenPept AAH31658 BAA90991 BAG61142 CAJ70648 CAX30832
RNA Seq Atlas 254394

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca