InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PHC2

Summary

InnateDB Gene

IDBG-95922.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHC2

Gene Name

polyhomeotic homolog 2 (Drosophila)

Synonyms

EDR2; HPH2; PH2

Species

Homo sapiens

Ensembl Gene

ENSG00000134686

Encoded Proteins

IDBP-95924

polyhomeotic homolog 2 (Drosophila)

IDBP-95928

polyhomeotic homolog 2 (Drosophila)

IDBP-95932

polyhomeotic homolog 2 (Drosophila)

IDBP-379309

polyhomeotic homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
In Drosophila melanogaster, the \'Polycomb\' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein \'polyhomeotic\' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:33323623-33431052

Strand

Reverse strand

Band

p35.1

Transcripts

ENST00000257118	ENSP00000257118
ENST00000373422	ENSP00000362521
ENST00000373418	ENSP00000362517
ENST00000431992	ENSP00000389436
ENST00000485928
ENST00000467894
ENST00000486897
ENST00000493483
ENST00000473158
ENST00000459964
ENST00000468406
ENST00000484692

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	72 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0031519	PcG protein complex
GO:0035102	PRC1 complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028796

View Gene Order

ENSBTAG00000004603

Not yet available

Pathways

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169274

Cellular Senescence pathway

REACT_169436

Oxidative Stress Induced Senescence pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.524271 Hs.619291

RefSeq

NM_004427 NM_198040 XM_005270568 XM_005270570 XM_005270571 XM_006710401 XM_006710402 XM_006710403

HUGO

OMIM

CCDS

CCDS378 CCDS379

HPRD

10340

IMGT

EMBL

GenPept

RNA Seq Atlas