Version 5.4
Homo sapiens Gene: TMPRSS15
Summary
InnateDB Gene IDBG-960.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMPRSS15
Gene Name transmembrane protease, serine 15
Synonyms ENTK; PRSS7
Species Homo sapiens
Ensembl Gene ENSG00000154646
Encoded Proteins
IDBP-962
transmembrane protease, serine 15
IDBP-360830
transmembrane protease, serine 15
IDBP-811646
transmembrane protease, serine 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:18269116-18485879
Strand Reverse strand
Band q21.1
Transcripts
ENST00000284885 ENSP00000284885
ENST00000422787 ENSP00000398253
ENST00000474775 ENSP00000474811
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0006898 receptor-mediated endocytosis
Cellular Component
GO:0005903 brush border
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022857
View Gene Order
ENSBTAG00000000597
Not yet available
Cross-References
SwissProt P98073
TrEMBL E9PG70 Q9NR95 V9QHE7
UniProt Splice Variant
Entrez Gene 5651
UniGene Hs.149473
RefSeq NM_002772
HUGO HGNC:9490
OMIM 606635
CCDS CCDS13571
HPRD
IMGT
EMBL AF246125 AL078474 AL109763 AL163217 AL163218 AP000455 AP000456 BC111749 KF688184 U09860 Y19124 Y19125 Y19126 Y19127 Y19128 Y19129 Y19130 Y19131 Y19132 Y19133 Y19134 Y19135 Y19136 Y19137 Y19138 Y19139 Y19140 Y19141 Y19142 Y19143
GenPept AAC50138 AAF97778 AAI11750 AHC28777 CAB65555 CAB90389 CAB90392
RNA Seq Atlas 5651

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca