Version 5.4
Homo sapiens Gene: RNF146
Summary
InnateDB Gene IDBG-96179.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF146
Gene Name ring finger protein 146
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000118518
Encoded Proteins
IDBP-96181
ring finger protein 146
IDBP-96183
ring finger protein 146
IDBP-96185
ring finger protein 146
IDBP-806314
ring finger protein 146
IDBP-806329
ring finger protein 146
IDBP-806352
ring finger protein 146
IDBP-806319
ring finger protein 146
IDBP-806331
ring finger protein 146
IDBP-806336
ring finger protein 146
IDBP-806339
ring finger protein 146
IDBP-806345
ring finger protein 146
IDBP-806357
ring finger protein 146
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:127266610-127288567
Strand Forward strand
Band q22.33
Transcripts
ENST00000368314 ENSP00000357297
ENST00000356799 ENSP00000349253
ENST00000309649 ENSP00000309365
ENST00000476956 ENSP00000477204
ENST00000495188
ENST00000477776 ENSP00000476867
ENST00000489534
ENST00000480444 ENSP00000476424
ENST00000609447 ENSP00000477019
ENST00000609944 ENSP00000477440
ENST00000608340
ENST00000610162 ENSP00000476888
ENST00000610153 ENSP00000476814
ENST00000608991 ENSP00000477168
ENST00000616343 ENSP00000479890
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0072572 poly-ADP-D-ribose binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051865 protein autoubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038876
View Gene Order
ENSBTAG00000034531
Not yet available
Pathways
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_200766
degradation of AXIN pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9NTX7
TrEMBL
UniProt Splice Variant
Entrez Gene 81847
UniGene
RefSeq NM_001242846 NM_030963 XM_006715571 NM_001242844 NM_001242845 NM_001242849 NM_001242850 NM_001242851 NM_001242852
HUGO HGNC:21336
OMIM 612137
CCDS CCDS5136 CCDS56449
HPRD
IMGT
EMBL AJ315122 AK027436 AK027558 AK027776 AL109939 AL136829 BC008235 CH471051 CR533514
GenPept AAH08235 BAB55108 BAB55196 BAB55359 CAB66763 CAB76254 CAB76255 CAC85986 CAG38545 EAW48109 EAW48111
RNA Seq Atlas 81847

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca