Version 5.4
Homo sapiens Gene: GRIK3
Summary
InnateDB Gene IDBG-96392.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIK3
Gene Name glutamate receptor, ionotropic, kainate 3
Synonyms EAA5; GLR7; GluK3; GLUR7; GluR7a
Species Homo sapiens
Ensembl Gene ENSG00000163873
Encoded Proteins
IDBP-96394
glutamate receptor, ionotropic, kainate 3
IDBP-96396
glutamate receptor, ionotropic, kainate 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:36795527-37034129
Strand Reverse strand
Band p34.3
Transcripts
ENST00000373093 ENSP00000362185
ENST00000373091 ENSP00000362183
ENST00000462621
ENST00000479620
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
GO:0004970 ionotropic glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005515 protein binding
GO:0008066 glutamate receptor activity
GO:0015277 kainate selective glutamate receptor activity
Biological Process
GO:0006810 transport
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007216 G-protein coupled glutamate receptor signaling pathway
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0051967 negative regulation of synaptic transmission, glutamatergic
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0032839 dendrite cytoplasm
GO:0032983 kainate selective glutamate receptor complex
GO:0042734 presynaptic membrane
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001985
View Gene Order
ENSBTAG00000009269
Not yet available
Pathways
NETPATH
REACTOME
REACT_21254
Presynaptic function of Kainate receptors pathway
REACT_13685
Neuronal System pathway
REACT_21322
Ionotropic activity of Kainate Receptors pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_21346
Activation of Ca-permeable Kainate Receptor pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.128848
RefSeq NM_000831
HUGO
OMIM
CCDS CCDS416
HPRD 00691
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca