Version 5.4
Homo sapiens Gene: MEAF6
Summary
InnateDB Gene IDBG-96417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEAF6
Gene Name MYST/Esa1-associated factor 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163875
Encoded Proteins
IDBP-96419
MYST/Esa1-associated factor 6
IDBP-96421
MYST/Esa1-associated factor 6
IDBP-96423
MYST/Esa1-associated factor 6
IDBP-96425
MYST/Esa1-associated factor 6
IDBP-380155
MYST/Esa1-associated factor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:37492575-37514774
Strand Reverse strand
Band p34.3
Transcripts
ENST00000296214 ENSP00000296214
ENST00000373075 ENSP00000362166
ENST00000373074 ENSP00000362165
ENST00000373073 ENSP00000362164
ENST00000448519 ENSP00000394966
ENST00000475828
ENST00000487788
ENST00000487792
ENST00000485039
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043968 histone H2A acetylation
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043983 histone H4-K12 acetylation
GO:0044154 histone H3-K14 acetylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0035267 NuA4 histone acetyltransferase complex
GO:0070776 MOZ/MORF histone acetyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028863
View Gene Order
ENSBTAG00000010506
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9HAF1
TrEMBL B1AK63
UniProt Splice Variant
Entrez Gene 64769
UniGene Hs.602917
RefSeq NM_001270875 NM_001270876 NM_022756 XM_006710821
HUGO HGNC:25674
OMIM 611001
CCDS CCDS418 CCDS59195 CCDS59196
HPRD
IMGT
EMBL AK021792 AL034379 AY211926 BC016328 BC056406 BX538212 BX640719 CH471059 DQ099384
GenPept AAH16328 AAH56406 AAO65179 AAZ13760 BAB13898 CAD98071 CAE45838 CAI20549 CAI20550 EAX07344
RNA Seq Atlas 64769

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca