InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RSPO1

Summary

InnateDB Gene

IDBG-96460.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RSPO1

Gene Name

R-spondin 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000169218

Encoded Proteins

IDBP-96464

R-spondin 1

IDBP-226698

R-spondin 1

IDBP-813728

R-spondin 1

IDBP-813730

R-spondin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:37611350-37634923

Strand

Reverse strand

Band

p34.3

Transcripts

ENST00000356545	ENSP00000348944
ENST00000401068	ENSP00000383846
ENST00000615459	ENSP00000481178
ENST00000612451	ENSP00000479832

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008201	heparin binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002090	regulation of receptor internalization
GO:0007140	male meiosis
GO:0010468	regulation of gene expression
GO:0030177	positive regulation of Wnt signaling pathway
GO:0060070	canonical Wnt signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000052	positive regulation of non-canonical Wnt signaling pathway
GO:2000254	regulation of male germ cell proliferation