InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ENPP3

Summary

InnateDB Gene

IDBG-96566.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENPP3

Gene Name

ectonucleotide pyrophosphatase/phosphodiesterase 3

Synonyms

B10; CD203c; NPP3; PD-IBETA; PDNP3

Species

Homo sapiens

Ensembl Gene

ENSG00000154269

Encoded Proteins

IDBP-96570

ectonucleotide pyrophosphatase/phosphodiesterase 3

IDBP-96595

ectonucleotide pyrophosphatase/phosphodiesterase 3

IDBP-387100

ectonucleotide pyrophosphatase/phosphodiesterase 3

IDBP-387105

ectonucleotide pyrophosphatase/phosphodiesterase 3

IDBP-387116

ectonucleotide pyrophosphatase/phosphodiesterase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:131628442-131747418

Strand

Forward strand

Band

q23.2

Transcripts

ENST00000357639	ENSP00000350265
ENST00000358229	ENSP00000350964
ENST00000427707	ENSP00000415589
ENST00000414305	ENSP00000406261
ENST00000423831	ENSP00000408642
ENST00000470930
ENST00000494023

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0004528	phosphodiesterase I activity
GO:0004551	nucleotide diphosphatase activity
GO:0005044	scavenger receptor activity
GO:0016787	hydrolase activity
GO:0030247	polysaccharide binding
GO:0035529	NADH pyrophosphatase activity
GO:0046872	metal ion binding
GO:0047429	nucleoside-triphosphate diphosphatase activity

Biological Process

GO:0006796	phosphate-containing compound metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0008152	metabolic process
GO:0009143	nucleoside triphosphate catabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019989

View Gene Order

ENSBTAG00000020196

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00740

Riboflavin metabolism pathway

hsa00770

Pantothenate and CoA biosynthesis pathway

hsa00760

Nicotinate and nicotinamide metabolism pathway

hsa00230

Purine metabolism pathway

hsa00500

Starch and sucrose metabolism pathway

INOH

INOH website

Nicotinate Nicotinamide metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.486489 Hs.604800 Hs.739146

RefSeq

NM_005021

HUGO

OMIM

CCDS

CCDS5148

HPRD

03715

IMGT

EMBL

GenPept

RNA Seq Atlas